Radon-222 is the decay product of radium-226. Radon-222 and its parent, radium-226, are part of the long decay chain for uranium-238. Since uranium is essentially ubiquitous (being or seeming to be everywhere at the same time) in the earth's crust, radium-226 and radon-222 are present in almost all rock and all soil and water.

The amount of radon in the soil depends on soil chemistry, which varies from one house to the next. Radon levels in the soil range from a few hundred to several thousands of pCi/L (picocuries per liter) in air. The amount of radon that escapes from the soil to enter the house depends on the weather, soil porosity, soil moisture, and the suction within the house.