The Nobel Assembly at the Swedish Karolinska Institutet today decided that the 2011 Nobel Prize in Physiology or Medicine should be divided, with one half jointly to Bruce A. Beutler, an American and Jules A. Hoffmann, a Luxembourger, for their discoveries concerning the activation of innate immunity and the other half to Ralph M. Steinman, a Canadian, for his discovery of the dendritic cell and its role in adaptive immunity.
Reuters reports that Canadian-born Ralph Steinman, 68, had been treating himself with a groundbreaking therapy based on his own research into the body's immune system but died on Friday after a four-year battle with pancreatic cancer. His colleagues at Rockefeller University in New York called it a "bittersweet" honour.
This year´s Nobel Laureates have revolutionized our understanding of the immune system by discovering key principles for its activation.
The Nobel Assembly said scientists have long been searching for the gatekeepers of the immune response by which man and other animals defend themselves against attack by bacteria and other microorganisms. Bruce Beutler and Jules Hoffmann discovered receptor proteins that can recognize such microorganisms and activate innate immunity, the first step in the body´s immune response. Ralph Steinman discovered the dendritic cells of the immune system and their unique capacity to activate and regulate adaptive immunity, the later stage of the immune response during which microorganisms are cleared from the body.
The discoveries of the three Nobel Laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms. Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases.
Two lines of defense in the immune system
The Nobel Assembly said we live in a dangerous world. Pathogenic microorganisms (bacteria, virus, fungi, and parasites) threaten us continuously but we are equipped with powerful defense mechanisms (please see figures on page 5). The first line of defense, innate immunity, can destroy invading microorganisms and trigger inflammation that contributes to blocking their assault. If microorganisms break through this defense line, adaptive immunity is called into action.
With its T and B cells, it produces antibodies and killer cells that destroy infected cells. After successfully combating the infectious assault, our adaptive immune system maintains an immunologic memory that allows a more rapid and powerful mobilization of defense forces next time the same microorganism attacks. These two defense lines of the immune system provide good protection against infections but they also pose a risk. If the activation threshold is too low, or if endogenous molecules can activate the system, inflammatory disease may follow.
The components of the immune system have been identified step by step during the 20th century. Thanks to a series of discoveries awarded the Nobel Prize, we know, for instance, how antibodies are constructed and how T cells recognize foreign substances. However, until the work of Beutler, Hoffmann and Steinman, the mechanisms triggering the activation of innate immunity and mediating the communication between innate and adaptive immunity remained enigmatic.
Discovering the sensors of innate immunity
Jules Hoffmann made his pioneering discovery in 1996, when he and his co-workers investigated how fruit flies combat infections. They had access to flies with mutations in several different genes including Toll, a gene previously found to be involved in embryonal development by Christiane Nüsslein-Volhard (Nobel Prize 1995). When Hoffmann infected his fruit flies with bacteria or fungi, he discovered that Toll mutants died because they could not mount an effective defense. He was also able to conclude that the product of the Toll gene was involved in sensing pathogenic microorganisms and Toll activation was needed for successful defense against them.
Bruce Beutler was
searching for a receptor that could bind the bacterial product,
lipopolysaccharide (LPS), which can cause septic shock, a life threatening
condition that involves overstimulation of the immune system. In 1998,
Beutler and his colleagues discovered that mice resistant to LPS had a
mutation in a gene that was quite similar to the Toll gene of the fruit fly.
This Toll-like receptor (TLR) turned out to be the elusive LPS receptor.
When it binds LPS, signals are activated that cause inflammation and, when
LPS doses are excessive, septic shock. These findings showed that mammals
and fruit flies use similar molecules to activate innate immunity when
encountering pathogenic microorganisms. The sensors of innate immunity had
finally been discovered.
A new cell type that controls adaptive immunity
Ralph Steinman discovered, in 1973, a new cell type that he called the dendritic cell. He speculated that it could be important in the immune system and went on to test whether dendritic cells could activate T cells, a cell type that has a key role in adaptive immunity and develops an immunologic memory against many different substances. In cell culture experiments, he showed that the presence of dendritic cells resulted in vivid responses of T cells to such substances. These findings were initially met with skepticism but subsequent work by Steinman demonstrated that dendritic cells have a unique capacity to activate T cells.
Further studies by Steinman and other scientists went on to address the question of how the adaptive immune system decides whether or not it should be activated when encountering various substances. Signals arising from the innate immune response and sensed by dendritic cells were shown to control T cell activation. This makes it possible for the immune system to react towards pathogenic microorganisms while avoiding an attack on the body´s own endogenous molecules.
From fundamental research to medical use
The discoveries that are awarded
the 2011 Nobel Prize have provided novel insights into the activation and
regulation of our immune system. They have made possible the development of
new methods for preventing and treating disease, for instance with improved
vaccines against infections and in attempts to stimulate the immune system
to attack tumors. These discoveries also help us understand why the immune
system can attack our own tissues, thus providing clues for novel treatment
of inflammatory diseases.
Jules A. Hoffmann was born in Echternach, Luxembourg in 1941. He studied at the University of Strasbourg in France, where he obtained his PhD in 1969. After postdoctoral training at the University of Marburg, Germany, he returned to Strasbourg, where he headed a research laboratory from 1974 to 2009. He has also served as director of the Institute for Molecular Cell Biology in Strasbourg and during 2007-2008 as President of the French National Academy of Sciences.
Ralph M. Steinman was born in 1943 in Montreal, Canada, where he studied biology and chemistry at McGill University. After studying medicine at Harvard Medical School in Boston, MA, USA, he received his MD in 1968. He has been affiliated with Rockefeller University in New York since 1970, has been professor of immunology at this institution since 1988, and is also director of its Center for Immunology and Immune Diseases.
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